ABSTRACT
Resumen Las feohifomicosis cerebrales son infecciones graves causadas por mohos dematiáceos, entre los cuales Cladophialophora bantiana es una de las especies más comúnmente aislada. Esta tiene tropismo por el sistema nervioso central y frecuentemente produce abscesos cerebrales en pacientes inmunocompetentes; además, en los inmunocomprometidos también puede ocasionar infección diseminada. Pese a la disponibilidad de medicamentos antifúngicos de amplio espectro, a menudo se requiere también la intervención quirúrgica; de todas maneras, la mortalidad es elevada. El diagnóstico debe hacerse interviniendo para tomar la muestra y hacer el cultivo y las pruebas de sensibilidad. Se presenta aquí el caso de un paciente con trasplante renal que presentó un absceso cerebral por C. bantiana, el cual se extrajo mediante resección quirúrgica. El paciente recibió tratamiento con voriconazol, con adecuada respuesta, mejoría y sin secuelas neurológicas.
Abstract Cerebral feohifomycosis are severe infections caused by dematiaceous fungi. Cladophialophora bantiana is one of the most commonly isolated species; it has central nervous system tropism and it often manifests as a brain abscess in immunocompetent patients. In immunocompromised patients, it can lead to brain abscesses and disseminated infections. Despite the availability of broad-spectrum antifungal drugs, it is a must to perform surgical management, in addition to drug therapy. However, mortality is high. The diagnostic approach must be invasive to establish a timely diagnosis and direct treatment based on culture and susceptibility tests. We report a case of brain abscess caused by C. bantiana in an immunosuppressed patient who was treated with surgical resection and voriconazole with an adequate response to therapy and without neurological sequels.
Subject(s)
Humans , Male , Middle Aged , Postoperative Complications/microbiology , Brain Abscess/microbiology , Kidney Transplantation , Saccharomycetales/isolation & purification , Cerebral Phaeohyphomycosis/microbiology , Postoperative Complications/surgery , Postoperative Complications/etiology , Postoperative Complications/drug therapy , Recurrence , Hyperoxaluria, Primary/complications , Hyperoxaluria, Primary/diagnosis , Hyperoxaluria, Primary/genetics , Brain Abscess/surgery , Brain Abscess/etiology , Brain Abscess/drug therapy , Amphotericin B/therapeutic use , Renal Dialysis , Immunocompromised Host , Combined Modality Therapy , Craniotomy , Nephrolithiasis/etiology , Cerebral Phaeohyphomycosis/surgery , Cerebral Phaeohyphomycosis/etiology , Cerebral Phaeohyphomycosis/drug therapy , Graft Rejection/drug therapy , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Antifungal Agents/therapeutic useABSTRACT
We report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole.
Subject(s)
Adolescent , Humans , Male , Fungemia/diagnosis , Fungemia/pathology , Hematologic Neoplasms/complications , Saccharomycetales/isolation & purification , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Echinocandins/therapeutic use , Fungemia/microbiology , Lung/pathology , Microbial Sensitivity Tests , Microbiological Techniques , Microscopy , Radiography, Thoracic , Treatment Outcome , Voriconazole/therapeutic useABSTRACT
Ear infections in cats are uncommon, especially involving yeasts. This report describes the first isolation of the Stephanoascus ciferrii, teleomorph of the Candida genus, in a case of feline otitis in Brazil. The identification and characterization of Stephanoascus ciferrii were confirmed by the Vitek2 System (BioMerieux ®).
Subject(s)
Animals , Cats , Cat Diseases/microbiology , Mycoses/veterinary , Otitis/veterinary , Saccharomycetales/isolation & purification , Brazil , Microscopy , Mycological Typing Techniques , Mycoses/microbiology , Otitis/microbiology , Saccharomycetales/cytology , Saccharomycetales/growth & development , Saccharomycetales/metabolismABSTRACT
The yeast Brettanomyces/Dekkeracan cause important spoilage in wines, with the production of ethylphenols and other off-flavor compounds. This study aimed at determining the presence of this yeast and the ethylphenols produced by them in Brazilian red wines, establishing their relationship with other chemical characteristics. Isolates of Brettanomyces/Dekkerawere quantified by plating 126 samples of dry red wine in selective culture medium, while ethylphenols were analyzed by solid phase extraction and GC/FID. Free and total SO2, alcohol, total dry extract, residual sugar, total and volatile acidity, and pH were also determined. Brettanomyces/Dekkerawas present in 27% of samples. Ethylphenols were detected in most samples, with amounts higher than the threshold limit of 426 mg/L found in 46.03% of samples. The majority of wine samples showed inadequate levels of SO2and residual sugars, facts that might facilitate microbial spoilage. The passage in barrels and the grape varieties (Cabernet Sauvignon and Merlot), did not show any influence on the levels of contamination or ethylphenols contents. The prevalence of Brettanomyces/Dekkeraand the concentrations of ethylphenols were high considering the sensory impact they can cause. The growth of Brettanomyces/Dekkerawas dependent on the levels of SO2and alcohol of wines. Knowledge of the contamination, the presence of ethylphenols, and their relationship with the chemical characteristics of wines can entice effective measures to prevent Brettanomyces/Dekkeraand contribute to improve the general quality of Brazilian red wines.